Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped Dose Response Curves
نویسندگان
چکیده
منابع مشابه
Superoxide dismutase, lipid peroxidation, and bell-shaped dose response curves.
Cellular metabolism generates the cytotoxic superoxide free radical, O(2).(-), and a family of enzymes called superoxide dismutases (SOD) protects us from O(2).(-) by catalyzing its conversion to O(2) and H(2)O(2). Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury. Most of the literature has described systems whe...
متن کاملSuperoxide Dismutase and Bell-shaped Dose Response Curves
BOOK April 29 – 30, 2008 University of Massachusetts, Amherst, MA Edward J. Calabrese, Ph.D. Paul T. Kostecki, Ph.D. Conference Directors
متن کاملStudy of Changes in Lipid Profile, Lipid Peroxidation and Superoxide Dismutase during Normal Pregnancy
Altered metabolic and hormonal status of the body in pregnancy leads to changes in lipid profile and oxidative stress. The present study was conducted to assess serum total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and triglycerides (TG) in healthy pregnant females and correlate these values with markers of oxidative str...
متن کاملColloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration-response curves suggest more complex biological effects, such as multiple-binding sites or multiple targets. Here, we investigate a physical property-based mechanism for bell-shaped curves. Beginning with the observation ...
متن کاملErythrocyte superoxide dismutase, catalase activities and hydrogen peroxide induced lipid peroxidation in leprosy.
OBJECTIVES To assess erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities and hydrogen peroxide induced lipid peroxidation in leprosy. DESIGN One hundred leprosy patients and 50 normal healthy controls were studied for the parameters. The data was analysed by grouping the patients into Ridley-Jopling (RJ) types [Tuberculoid leprosy (TT, n = 22), Borderline tuberculoid leprosy ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Dose-Response
سال: 2008
ISSN: 1559-3258,1559-3258
DOI: 10.2203/dose-response.08-012.mccord